This mistake which rarely occurs causes the blood in the sample to clot before it is tested. However, the MPV readings are elevated in women who have given birth recently.Ī mistake in the collection of blood sample is also regarded as a reason for a low MPV reading. Low reading of MPV is also observed in infants and newborns, which is completely normal. Normal Conditionsįemales usually have a low reading of MPV in the initial days of her menses. Besides this, a low MPV is also considered a symptom of many other diseases and disorders. Having a Low MPV indicates that the platelet count in your blood is lower than normal and that you are in danger of suffering more blood loss in case you get injured. However, in most cases a reading in between 9.7 to 12.8 fL is considered safe which corresponds to spheres having diameters of 2.65 to 2.9 µm. The volume of the platelets is calculated in femtoliter which is denoted by “fL”, and under normal circumstances ranges in between 7.5 fL to 11.5 fL. It can provide the doctors with the knowledge of whether the body is generating more platelets than normal since the size of the platelet becomes enlarged in such circumstances. The use of this reading is made in determining the rate of production of platelets in patients who are suffering from problems or diseases related to platelet destruction or bone morrow. CBC or Complete Blood Profile is the test in which the calculation of this reading is usually included. It is a reading which represents the size of the platelets in a blood sample and is determined by a machine. Our findings may provide interesting insight into the effect of platelet life span and turnover on aspirin resistance.MPV is the abbreviated form of Mean Platelet Volume. High MPV, commonly due to younger and more aggregable platelets, is associated with arachidonic acid– and collagen‐defined aspirin resistance independent of cardiovascular risk factors and native platelet reactivity. After adjusting for agonist‐specific pre‐ASA platelet aggregation (Figure, lower), MPV remained associated with aspirin resistance as defined by collagen and arachidonic acid but was no longer associated with ADP‐defined aspirin resistance. This association remained significant after adjusting for age, sex, race, hypertension, diabetes, low‐density lipoprotein cholesterol, smoking status, and fibrinogen (Figure, upper). In unadjusted analysis, MPV was associated with aspirin resistance as defined by each agonist and dose. Mean (SD) age was 45.9 (13.5) years 55% were female 40% African American 25% current smokers, 37% hypertensive, and 12% diabetic. We used logistic regression with adjustment for familial relationship. For collagen and ADP, individuals in the highest quartile of aggregation after ASA therapy were defined as aspirin resistant. Individuals with any arachidonic acid–mediated aggregation were defined as aspirin resistant. For each dose of each agonist, we examined the association between MPV and aspirin resistance separately. Optical aggregation was measured in platelet‐rich plasma after samples were stimulated with collagen (2 and 5 μg/mL), ADP (2 and 10 μmol/L), or arachidonic acid (1.6 mmol/L) before and after 14 days of ASA therapy. Methods:įasting blood samples were obtained from healthy participants ( n = 2363 from 584 families) with a family history of premature coronary artery disease. Our aim was to examine whether individuals with high MPV are more likely to have aspirin resistance. However, a relationship between high MPV and aspirin resistance, as measured by platelet aggregation, has not been reported. Aspirin (ASA) resistance and high mean platelet volume (MPV) are associated with increased risk for cardiovascular events.
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